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Co-Supervisor: Dr. FLISZÁR-NYÚL, Eszter

We develop HPLC-based analytical methods to characterize protein sulfhydryl persulfidation and polysulfide metabolite formation after interaction with sulfide and polysulfides. 

Endometriosis is a chronic, estrogen-dependent gynecological disorder characterized by the presence of endometrium-like tissue outside the uterus. Our preliminary studies have demonstrated that the expression of matrix metalloproteinases (MMPs), as well as signaling pathways associated with transforming growth factor beta (TGF-β), is elevated in ectopic endometriotic cells compared to normal endometrial cells. This study aims to investigate the role of MMPs and the TGF-β signaling pathway using human endometriosis cell lines, with particular emphasis on changes on their cellular proliferation, viability, and migration.

Co-Supervisor: Dr. NAGY, András

In our study, we are going to use questionnaires to compare the mood and assess the mental health of individuals taking SGLT2 inhibitors versus those not using them. The study contributes to the understanding of potential effects of SGLT2 inhibitors on mood, which could lead to more comprehensive treatment approaches for individuals facing both diabetes and mood disorders.

Co-Supervisor: Dr. NAGY, András

In our study, we establish depression-like behavior in mice. We assess the behavior of mice treated with SGLT2 inhibitors versus control in tests characterizing anxiety and depression-like behavior. We collect brain samples and investigate neuronal activation of brain erase related to anxiety and depression with immunohistochemistry. The study contributes to the understanding of potential effects of SGLT2 inhibitors on mood, which could lead to more comprehensive treatment approaches for individuals facing both diabetes and mood disorders.

Co-Supervisor: GÖNTÉR, Kitti

In this topic we will study the effects of DMTS, an organic polysulphide, in a mouse model of anxiety and depression. Regarding the underlying mechanism, we investigate the endocannabinoid system. DMTS is likely to inhibit the main enzymes that degrade endocannabinoids by forming a disulfide bond with their cysteine side chains. Inhibition of these enzymes increases the endocannabinoid level in the CNS, reducing the effects of acute and chronic stress and the risk of depression.

Co-Supervisor: GÖNTÉR, Kitti

Investigation of transdermal dimethyl trisulfide absorption from solution, gel and patch formulations by HPLC