Tantargy

Data

Official data in SubjectManager for the following academic year: 2024-2025

Topic

The main objective of this course is to expand the knowledge in phyisico-chemical characterization of drug molecules and drug targets for better understanding the drug action.

Lectures

• 1. Molecular bases of biological actions. Structural characteristics of drug targets. - Rozmer Zsuzsanna
• 2. Molecular bases of biological actions. Structural characteristics of drug targets. - Rozmer Zsuzsanna
• 3. Receptors as drug targets. - Rozmer Zsuzsanna
• 4. Receptors as drug targets. - Rozmer Zsuzsanna
• 5. Enzymes as drug targets. - Rozmer Zsuzsanna
• 6. Enzymes as drug targets. - Rozmer Zsuzsanna
• 7. Transporters and ion channels as drug targets. - Rozmer Zsuzsanna
• 8. Transporters and ion channels as drug targets. - Rozmer Zsuzsanna
• 9. Nucleic acids as drug targets. - Rozmer Zsuzsanna
• 10. Nucleic acids as drug targets. - Rozmer Zsuzsanna
• 11. Physicochemical properties of drug-drug target interactions. Intermolecular bonding. - Rozmer Zsuzsanna
• 12. Physicochemical properties of drug-drug target interactions. Intermolecular bonding. - Rozmer Zsuzsanna
• 13. Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity. - Rozmer Zsuzsanna
• 14. Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity. - Rozmer Zsuzsanna
• 15. Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry. - Rozmer Zsuzsanna
• 16. Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry. - Rozmer Zsuzsanna
• 17. Physicochemical characteristics of drugs. Solubility. - Rozmer Zsuzsanna
• 18. Physicochemical characteristics of drugs. Solubility. - Rozmer Zsuzsanna
• 19. Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value. - Rozmer Zsuzsanna
• 20. Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value. - Rozmer Zsuzsanna
• 21. Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients. - Rozmer Zsuzsanna
• 22. Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients. - Rozmer Zsuzsanna
• 23. Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability. - Rozmer Zsuzsanna
• 24. Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability. - Rozmer Zsuzsanna
• 25. In silico ADME modelling. In vitro and in vivo tests. - Rozmer Zsuzsanna
• 26. In silico ADME modelling. In vitro and in vivo tests. - Rozmer Zsuzsanna
• 27. Physicochemical characteristics of drugs. Metabolic stability. - Rozmer Zsuzsanna
• 28. Physicochemical characteristics of drugs. Metabolic stability. - Rozmer Zsuzsanna

Practices

Seminars

Reading material

Obligatory literature

-

Literature developed by the Department

PPT slides of the lectures

Notes

Zsuzsanna Rozmer, Pál Perjési: The physico-chemical bases of drug actions. PTE, 2015.

Recommended literature

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Conditions for acceptance of the semester

Successful written exam.

Mid-term exams

Written test.

Making up for missed classes

None.

Exam topics/questions

Topics of the written tests are set by the course director.

Examiners

Instructor / tutor of practices and seminars

• Rozmer Zsuzsanna